The unique environment of microgravity offers much for the discovery of new targets and their validation by both experimental drug candidates and approved medicines. This presentation will review the drug discovery and development process and provide examples of where the microgravity assist has opened up new opportunities for the treatment of both terrestrial disease and the possible maintenance of astronaut health with a longer term view of colonisation of other worlds. Finally, we will glimpse into a possible future of AI-assisted drug discovery and the potential acceleration of regenerative medicine.